Item: Dead Tooth
1-3 Blue flies randomly spawn every time Isaac gets hit.
Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item). Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick). Enemies that were poisoned have a chance to drop a black heart when killed.
Spear of Destiny
In addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy.
Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.
Sets the amount of red heart containers to 1, but gives Isaac 9 extra lives. After dying, Isaac is teleported to the last safe room. New heart containers can be obtained after picking up this item, but after each death, the number of heart containers is set to 1 again.
After taking damage a certain amount of times, a permanent demonic familiar spawns.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Charm of the Vampire
Heals the character for half of a red heart for every 13 monsters killed.
Zodiac will give Isaac a random zodiac item effect that changes after every floor.
Increases damage by 1 and speed by 0.4.
All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
Grants one red heart container, restores 5 red hearts, and increases speed by 0.3.