Item: Death's List

This item will boost one of Isaac's stats depending on the color of the aura around him. The aura will disappear upon taking damage and will reappear with a random color upon entering a new room. A red aura boosts damage, a blue aura boosts rate of fire, a yellow aura boosts speed, and an orange aura boosts range.

Grants flight and one heart container.

Removed in Afterbirth: Automatically inflicts slow to all enemies in every room.
Added in Afterbirth: Upon taking damage, inflicts slow to all enemies for the current room.

One of two parts necessary to create Mom's Shovel.

Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.

Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.

Tears are replaced with laser rings that pierce through enemies and deal damage to enemies within them. Can be charged to increase the size of the ring.

Grants one full red heart container.

Increases Damage by 1, and turns Isaac's tears into blood tears.

Grants triple shot but decreases tears.

Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.

Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.

Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.

Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.

Spawns 4 random pills around Isaac.

Increases range and shot speed, while adding 1 Black Heart.

Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.

Spawns a chest familiar that follows Isaac and drops a random pickup every few rooms.

Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.

Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.