Item: Death's Touch
Spawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket.
One of two parts necessary to create Mom's Shovel.
Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
Spirit of the Night
Grants spectral tears and flight.
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Cube of Meat
Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Adds one filled heart container and increases Shot Speed.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Money = Power
Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.
Key Piece 2
Combined with Key Piece 1, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
+1 luck. Spawns a fairy familiar that points out secret room entrances and tinted rocks.