Item: Deep Pockets
Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
Blood of the Martyr
Increases Damage by 1, and turns Isaac's tears into blood tears.
Isaac's tears split in two when they hit something.
Allows Isaac to carry two cards, pills, or any combination of both at the same time. Drops a random card or pill.
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
Reveals all rooms for every floor. However, it does not reveal icons or secret rooms.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
A portable beggar who follows Isaac, picks up coins for himself, and occasionally drops a pickupafter collecting a coin. Does not spawn collectibles.
Greatly increases the chance to find sacks.
Wanders about the room, occasionally spawning blue spiders.
Isaac's tears are replaced by a knife that pierces enemies, can travel through obstacles, and can hurt enemies while Isaac is holding it. Holding down the fire button before firing increases its range and power.
Two items spawn in every Treasure Room. Only one can be taken; the other will disappear.
Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.