Definition of Category
Deploys a decoy Isaac that eventually explodes with an increased blast radius.
Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.
Spawns a stationary fly familiar that fires tears at nearby enemies.
Increases speed and reduces character size. Also gives a random pill.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Throwing the ball at an enemy instantly kills it and captures it. The captured enemy can later be released and will be charmed until it dies, persisting between floors.
Upon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine.
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
When used, converts two soul hearts into a heart container.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Grants Isaac one full red heart container.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Adds one soul heart and allows the breaking of rocksand damaging enemies by simply walking over them. Increases damage and decreases speed. All effects except for the Soul Heart wear off upon leaving the room.
+5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
Increases all stats and enlargens Isaac.
+1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
A glass of milk follows Isaac and spills on the floor upon taking damage. After the milk spills, Isaac's tear delay is decreased by 2 for the rest of the room.
Breath of Life
Grants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage.