Definition of Description
A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Activated Items can be "overcharged" to allow for an additional use.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Isaac can hold 2 pills at once and all cards are replaced by pills.
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Spawns a penny and has a 50% chance to double all items and pickups in the room. If the effect fails, the items and pickups disappear.
While firing, Isaac gains a green aura that poisons nearby enemies.
Adds one empty heart container. Whenever Isaac takes damage there's a chance that a Red Heart may drop.
Upon use, Isaac fires a laser similar to the one used by Mega Satan. This laser deals massive damage, lasts for approximately 15 seconds, and persists between rooms. Isaac is pushed backwards by the force of the laser while it is active.
Spider enemies no longer target or deal contact damage to Isaac.
Gives one heart container and doubles the healing provided by red hearts.
Tears fired from left eye do increased damage.
Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
A familiar that drops a Little Battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit.
Blood of the Martyr
Increases Damage by 1, and turns Isaac's tears into blood tears.
Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Telepathy for Dummies
Upon activation, grants homing tears for the current room.
Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.