Definition of DLC Required

DLC Required
Item ID
Icon
Description

Isaac's Tears

323
Isaac's Tears
Shoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.
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Duality

498
Duality
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
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Magneto

53
Magneto
Pulls pickups towards Isaac.
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Technology Zero

524
Technology Zero
Connects Isaac's tears with electricity that can damage enemies.
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Eden's Soul

490
Eden's Soul
Spawns two item pedestals.
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The Gamekid

93
The Gamekid
Upon use, turns the character into a into a Pac-Man-like creature for 5 seconds, granting invulnerability, inflicting fear on all enemies, and replenishing half a red heart container for every two enemies killed.
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Bomber Boy

353
Bomber Boy
+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.
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8 Inch Nails

359
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
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Glyph of Balance

464
Glyph of Balance
Grants 2 soul hearts and modifies drops from Champion Monsters based on certain conditions.
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Mom's Contacts

110
Mom's Contacts
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
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Dead Bird

117
Dead Bird
Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.
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Dessert

24
Dessert
Grants Isaac one full red heart container.
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<3

15
<3
Grants Isaac one red heart container and fully restores Isaac's health.
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Cupid's Arrow

48
Cupid's Arrow
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
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Harlequin Baby

167
Harlequin Baby
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
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Chaos

402
Chaos
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
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Smart Fly

264
Smart Fly
After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
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D1

476
D1
Duplicates a random pickup in the room.
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Backstabber

506
Backstabber
Has a chance to fire tears that inflict bleeding on enemies, causing them to slowly take damage over time.
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Pyromaniac

223
Pyromaniac
Isaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.
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