Definition of Icon
Tears fired from left eye do increased damage.
Makes Isaac shoot one huge tear. Also reduces Tears to minimum. Damage increased . If tear does more damage than an enemy's life, the tear continues to travel with the extra remaining damage.
Damages all enemies in the room, but deals a heart of damage to Isaac with each use.
After taking damage a certain amount of times, a permanent demonic familiar spawns.
+1.7 tears, +0.3 speed, reduces damage.
Upon use, Isaac farts, charming all nearby enemies.
Telepathy for Dummies
Upon activation, grants homing tears for the current room.
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Gives +5 bombs and makes all bombs Butt Bombs that fill the room with gas, damaging and confusing all enemies.
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
Cain's Other Eye
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to The Peeperand shoots normal tears in the same direction as Isaac.
Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Grants one soul heart. Upon entering a boss room, grants a shield that blocks one hit, then disappears.