Definition of Item ID

While held, causes multiple Mom's Foots to come down and stomp on Isaac. One of two parts necessary to create Mom's Shovel.

Throws a black hole on the ground which sucks in and damages enemies.

Upon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room.

Removed in Afterbirth: Automatically inflicts slow to all enemies in every room.
Added in Afterbirth: Upon taking damage, inflicts slow to all enemies for the current room.

If the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room.

Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.

Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.

Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.

Isaac can hold 2 pills at once and all cards are replaced by pills.

Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.

Rerolls all pickups in the current room.

Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.

Tears fired from left eye do increased damage.

Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.

Grants an empty heart container. Increases damage, range and shot height while reducing speed.

+0.5 tears up, +0.2 shot speed up.

Grants flaming tears that deal burning damage over time. Tears have a chance to explode on impact with an enemy, which creates a fire at the location of the explosion.

When used, teleports Isaac to a random room that has not been explored yet. If all rooms are explored, including secret rooms, it will teleport Isaac to the Devil or Angel room. If all rooms are explored, including the Devil or Angel room, it will teleport Isaac to the I AM ERROR room. If used in a room with enemies, it will teleport Isaac out and back into the exact same room.

Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.

Isaac is followed by a small bag that drops a coin every 2 rooms.