Definition of Use

Allows Isaac to hold two active items.

Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.

Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.

Gives Isaac 99 coins. Can be found multiple times in a single playthrough.

Upon use, Isaac farts, charming all nearby enemies.

Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.

Grants spectral tears and flight.

Reveals all special rooms (except secret rooms of any kind).

Grants flight and one eternal heart.

Adds 1 heart container.

Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.

-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.

Restarts the current room and brings back all enemies, allowing more rewards to be acquired by completing the room.

When used, Mom's Box will drop a random trinket on the ground. While held, increases luck by 1 and doubles the effects of trinkets.

Duplicates a random pickup in the room.

Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.

Grants four soul hearts and fully restores Isaac's red health.

Upon use, creates a protective shield nullifying all types of damage for 10 seconds.

Grants spectral tears and flight.

Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.