Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.
Eye of Greed
Adds a chance to fire tears that temporarily stun enemies and turn them into gold. Any enemy killed while in this state will drop coins.
Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Spirit of the Night
Grants spectral tears and flight.
A familiar that follows Isaac around shooting blood tears.
Adds a chance to fire a booger which sticks to enemies and poisons them.
Gives Isaac 99 coins. Can be found multiple times in a single playthrough.
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
Once per room, when Isaac is reduced to his last half red Heart, the aura around his head temporarily vanishes and he is granted one Soul Heart.
Spawns a finger familiar that points at enemies, dealing constant damage.
Greatly increases the chance to find sacks.
+1.7 tears, +0.3 speed, reduces damage.
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.