Spawns a familiar that slowly charges forward and damages enemies in its path.
Automatically negates first taken damage in every room.
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 7 seconds.
A Lump of Coal
The more distance tears travel, the more damage they will do.
Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
Reveals all special rooms (except secret rooms of any kind).
All standard bomb pickups become 1+1 bomb pickups.
???'s Only Friend
Summons a big attack fly that can be controlled with the shooting direction-keys.
Adds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Grants a heart container for every 25 coins Isaac has.
A familiar who will drop a half red heart every 2 rooms.
A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Isaac's tears gain a random effect that changes every shot.