Item: E Coli
Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
-1 Tear Delay, adds knock-back shots and increases tear size.
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
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Summons a big attack fly that can be controlled with the shooting direction-keys.
Randomizes all passive items upon pickup and at the start of each succeeding floor.
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Adds a chance to shoot petrifying tears, which stop enemies in place and prevent them from moving or attacking. Range up.
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Isaac's tears gain a random effect that changes every shot.
Spawns a familiar that follows Isaac around and blocks enemy projectiles. Upon blocking a shot, it has a chance of triggering The Necronomicon effect.
Increases tears. Adds a chance to fire a high-damage razor blade.
Gives Isaac's tears a boomerang effect, and increases range and shot speed.
+0.3 tears up. Allows Isaac to fire tears diagonally.
Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard?pill. Isaac's tears also travel above all obstacles.
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Adds a chance to fire a gas cloud that damages nearby enemies.
Increases damage and speed, removes all red heart containers, grants six black hearts, and adds a chance to shoot fear tears.