Item: Eden's Blessing
Spawns 2 keys. Generates additional pickups from chests.
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Shooting in one direction increases Isaac's rate of fire until the cap is reached. As soon as Isaac changes direction or stops shooting, rate of fire is reset to its normal amount.
Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item). Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick). Enemies that were poisoned have a chance to drop a black heart when killed.
While firing, Isaac gains a green aura that poisons nearby enemies.
Grants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.
Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Spawns a white poop familiar, which turns into a white poop when Isaac is hurt.
Replaces tears with a piercing laser with unlimited range.
Spawns a random pill, and grants a small Spewer familiar that charges up and fires different types of creep.
Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or keyafter clearing a room.
Increases damage and speed. Upon entering a room adjacent to a secret room, a howl sound effect will play.
Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard?pill. Isaac's tears also travel above all obstacles.
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Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.