Item: Eve's Mascara
Tears up, adds 1 soul heart, and decreases Isaac's size.
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Adds a chance to fire a booger which sticks to enemies and poisons them.
Isaac heals 1 heart instead of taking damage from an explosive source. Adds 5 bombs.
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
Increases speed by 0.3 and shot speed by 20%.
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
All standard bomb pickups become 1+1 bomb pickups.
Reveals all special rooms (except secret rooms of any kind).
Key Piece 1
Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Drops a random trinket. Grants a second trinket slot.
Spawns a familiar that flies around the room in a manner similar to the Boom Fly and explodes on contact with an enemy. Respawns after ten seconds.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
A familiar who will drop a half red heart every 2 rooms.
Increases Damage by 1.5, reduces Tears by 0.3 and increases tear size. Grants piercing tears. Tears are replaced by Death's scythes, which is a cosmetic effect only.
Circle of Protection
Surrounds Isaac with a large white halo around him that pulsates. With each pulse, the halo deals contact damage to enemies equal to Isaac's damage. Each pulse also converts any enemy shots touching the ring into friendly purple homing tears.