Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Increases damage and range while reducing shot speed and grants homing tears. Grants a Heart Container and replenishes all Red Hearts.
Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Adds a chance to shoot a fire that damages enemies and remains in place until it deals enough damage or the room is left.
When Isaac is hit, 1 point of an item's charge is filled.
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Increases damage by 1 and range by 5 for tears fired from the left eye.
Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Spawns a familiar that drops random pills every 2 rooms cleared. Upon using a pill, all enemies in the room are poisoned.
Adds 3 Soul Hearts and increases the chance for The Bible to appear in any item pool.
Eye of Greed
Adds a chance to fire tears that temporarily stun enemies and turn them into gold. Any enemy killed while in this state will drop coins.
A bag that follows Isaac and drops a random rune every 3 rooms.
Isaac's head is removed from his body and floats around him. Increases Damage by 1 and grants -1 Tear Delay.