Item: Flat Stone
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
Gives Isaac 99 coins. Can be found multiple times in a single playthrough.
Grants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.
Spawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Upon picking up a certain amount of health, spawn a permanent angelic familiar.
+1.25 Range Up. +0.5 Tear Height. +1 Luck Up.
Drops a random trinket. Grants a second trinket slot.
Familiar that follows Isaac, leaving blood creep on the ground.
Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Fliesdamaging enemies it passes through.
Cube of Meat
Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
If the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room.
Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Grants an empty heart container. Increases damage, range and shot height while reducing speed.
Adds a chance to fire a gas cloud that damages nearby enemies.