+0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.
Prevents curses. Grants one black heart. Increases the chance for a Devil or angel room to appear.
Adds a chance to fire a booger which sticks to enemies and poisons them.
Summons a familiar that copies the tears of Isaac's other familiars.
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
Sack of Sacks
Spawns a sack familiar that has a chance to drop a sack upon clearing a room.
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Grants a familiar that transforms into another random familiar every 10 seconds.
Whore of Babylon
Increases damage and speed whenever Isaac has half a red heart or less (one red heart for Eve), ignoring any soul or black hearts.
Tears shrink and do much less damage, but fire in very rapid succession.
Adds a chance to spawn blue spiders when firing tears. Restores 1 red heart.
Zodiac will give Isaac a random zodiac item effect that changes after every floor.
Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
+1.7 tears, +0.3 speed, reduces damage.
Two items spawn in every Treasure Room. Only one can be taken; the other will disappear.