+0.25 Speed. Running into enemies while at a high speed will deal 18 points of damage. Does not prevent contact damage.
A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
+0.3 tears up. Allows Isaac to fire tears diagonally.
Drops a random card or rune. Doubles the effects of cards and runes.
Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
Tears up, adds 1 soul heart, and decreases Isaac's size.
Gives one heart container and doubles the healing provided by red hearts.
Tears and Range up. Spawns 3 random types of hearts on the floor when picked up.
Increases damage by 0.3 and adds a chance to shoot concussive tears, causing enemies to walk around randomly.
Reveals all rooms for every floor. However, it does not reveal icons or secret rooms.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
1-3 Blue flies randomly spawn every time Isaac gets hit.
The Ludovico Technique
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Gives 5 bombs and grants all bombs poison effect.
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Follows Isaac and automatically fires at enemies in its reach.
Grants an active item charge every 15 enemies killed.