Spawns a white poop familiar, which turns into a white poop when Isaac is hurt.
Chance to block projectiles coming from any direction.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Adds 25 to Isaac's coin count, capping at 99.
Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.
Increases damage. Adds a chance to fire acidic tears which can destroy obstacles.
An angel familiar which follows Isaac and fires homing tears which deal 10 damage at -25% shot speed and a reduced fire rate.
When hit, spawns up to 2 blue spiders.
Grants Isaac a permanent 50% chance to respawn with 1/2 of a red heart after death.
Grants poison tears, which deal damage over time when inflicted.
Tears bounce off walls, enemies, and environmental objects.
Spawns a chest familiar that follows Isaac and drops a random pickup every few rooms.
Buddy in a Box
Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
A blue fly familiar follows Isaac's movements on a 3 second delay. Papa Fly will fire tears at nearby enemies.
Spirit of the Night
Grants spectral tears and flight.
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.