Item: God's Flesh
Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Summons a familiar that copies the tears of Isaac's other familiars.
Buddy in a Box
Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.
Adds a chance to fire a booger which sticks to enemies and poisons them.
???'s Only Friend
Summons a big attack fly that can be controlled with the shooting direction-keys.
Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.
Tears bounce off walls, enemies, and environmental objects.
Isaac emits a beam from his face. Isaac's tears travel in the path of the beam.
Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. In the burst of tears is a kidney stone which deals a lot of damage.
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Increases damage, and adds 1 heart container.
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Drops a random card or rune. Doubles the effects of cards and runes.
A Lump of Coal
The more distance tears travel, the more damage they will do.
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
Isaac's tears gain a random effect that changes every shot.
Prevents curses. Grants one black heart. Increases the chance for a Devil or angel room to appear.
A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room. If any enemies walk into its path, it will deal 7 contact damage per tick. If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.