Item: Guardian Angel
Reveals all special rooms (except secret rooms of any kind).
+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.
Grants 7 bombs and allows bombs to be placed rapidly.
Sack of Sacks
Spawns a sack familiar that has a chance to drop a sack upon clearing a room.
Each time Isaac kills an enemy, Isaac's damage increases for the current room.
Adds one empty heart container. Whenever Isaac takes damage there's a chance that a Red Heart may drop.
Activated Items can be "overcharged" to allow for an additional use.
Mom's Coin Purse
Spawns 4 random pills around Isaac.
Isaac can hold 2 cards at once and all pills are replaced by cards.
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
+1.7 tears, +0.3 speed, reduces damage.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Spawns a familiar that drops random pills every 2 rooms cleared. Upon using a pill, all enemies in the room are poisoned.
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
+1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat)