Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
Grants a reward if all enemies in a room are killed in the order they are marked.
Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Grants two soul hearts. Isaac now repels enemy projectiles.
Gives 6 coins, 6 bombs, and 6 keys and balances out all attributes.
Spawns a finger familiar that points at enemies, dealing constant damage.
+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.
Grants one bone heart and spawns three red heart pickups.
Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Has a chance to fire tears that inflict bleeding on enemies, causing them to slowly take damage over time.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
A familiar that drops a Little Battery every 4 rooms. Has a small chance to freeze all enemies in the room when hit.
Spawns allied blue spiders from killed enemies.
Gives 3 pennies on pick-up. Every time Isaac is damaged, he will drop one additional penny.