Item: Guppy's Head
Upon use, rerolls all passive items on Isaac like the D4, every pedestal item in the room like The D6, and every pickup like the D20.
Kills all enemies in the room, then kills Isaac three seconds later.
When used, Mom's Box will drop a random trinket on the ground. While held, increases luck by 1 and doubles the effects of trinkets.
Removes a heart container, increases damage and range, and grants a Cube of Meat.
Glowing Hour Glass
When used, this item will rewind time, put Isaac back in the previous room, and undo anything that happened in the current room. Any health, pickups, or items gained or lost will be reset back to the previous state.
Summons a random familiar for the current room. Can summon familiars not yet unlocked.
Upon use, Isaac farts, charming all nearby enemies.
Book of Shadows
Upon use, creates a protective shield nullifying all types of damage for 10 seconds.
Monstro jumps onto a random enemy, doing area damage. Can damage/kill the player if summoned in an room without enemies.
Head of Krampus
Fires a cross-patterned brimstone shot, just like The Fallen and Krampus shoot.
When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies near Isaac, and send a wave of spikes that deals 10 damage across the room in the direction Isaac is facing.
The Book of Sin
Spawns a random pickup, pill, card, or trinket.
Grants a random dice item that changes each use.
When used, copies the effect of the pill Isaac is currently holding without consuming it. Does not copy the effects of cards or runes.
Upon use, turns Isaac's head into a stationary familiar for the current room which fires normal tears that deal 3.5 damage.
If the box is empty, picks up all items and pickups in a room and stores them. If the box is not empty, places all stored items and pickups in the current room.
Shoop Da Whoop!
Fires a laser from Isaac's mouth.