Item: Head of the Keeper
Upon dying, resurrect as Revived Lazarus with one heart container and Anemic item.
Adds 25 to Isaac's coin count, capping at 99.
Grants a reward if all enemies in a room are killed in the order they are marked.
Dagger orbits Isaac, dealing very high damage.
Increases damage and increases the chance for a Devil or Angel Room to appear.
Adds a chance to fire an egg sack which spawns slowing creep and spawns a blue fly or spider upon hitting an enemy.
Has a chance of spawning a soul heart or black heart when taking damage. Enemies have a chance to drop a Half Red Heart after being killed.
Allows Isaac to fire tears from the back of his head.
Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.
Grants an active item charge every 15 enemies killed.
Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Converts all bad pills into good pills, spawns one pill pickup and restores health. Identifies all pills upon pickup.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
Isaac can hold 2 cards at once and all pills are replaced by cards.