Item: Headless Baby

Activated Items can be "overcharged" to allow for an additional use.

Increases damage and increases the chance for a Devil or Angel Room to appear.

Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard?pill. Isaac's tears also travel above all obstacles.

Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.

Removed in Afterbirth: Automatically inflicts slow to all enemies in every room.
Added in Afterbirth: Upon taking damage, inflicts slow to all enemies for the current room.

Increases all stats and enlargens Isaac.

Adds a chance to fire needles. If a needle kills an enemy, it bursts into more needles.

Spawns a familiar that slowly charges forward and damages enemies in its path.

Grants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.

Increases speed by 0.6, range by 5.25, and tear height by 0.5.

Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.

-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.

Enemies, enemy shots, tears, and pickups will briefly freeze in place at random intervals.

Increases damage by 0.04 for every coin Isaac has, up to +3.96 damage at 99 coins.

The first enemy killed in a room explodes and poisons nearby enemies. Poisoned enemies will also explode upon death.

Increases range.

Tears have a chance to charm enemies.

Grants one bone heart and spawns three red heart pickups.

Spawns a familiar that flies the room while firing, dealing double Isaac's tear damage to enemies that come in contact and retrieving pickups.

Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.