Item: Holy Water
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Tears shrink and do much less damage, but fire in very rapid succession.
When Isaac is hit, 1 point of an item's charge is filled.
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Upon picking up a certain amount of health, spawn a permanent angelic familiar.
Grants 1 heart container and increases tears, but decreases shot speed.
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
Grants charged tears that can be fired in a tight burst of four. Getting hit while charging will teleport Isaac into another room.
Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.
While firing, Isaac gains a green aura that poisons nearby enemies.
Doubles damage, halves tears stat, and greatly reduces shot speed.
When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Isaac has a random chance to fire a Holy tear, which, when it hits an enemy, will spawn a Crack the Sky-style light beam on the same enemy, dealing damage.
Increases damage as Isaac receives damage. Damage increase stays for the whole floor.