Item: Immaculate Conception
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
+1.7 tears, +0.3 speed, reduces damage.
Reveals all special rooms (except secret rooms of any kind).
Mom's Coin Purse
Spawns 4 random pills around Isaac.
Buddy in a Box
Grants a familiar with a random tear effect. The familiar is randomized at the start of each floor.
Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
Gives Isaac a golden censer familiar which creates a huge aura of light that slows down any enemies and enemy shots inside it.
Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.
Increases range and shot height.
Lord of the Pit
Grants flight and increases speed.
Spirit of the Night
Grants spectral tears and flight.
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Taking damage releases a ring of 10 high damage tears.
Adds a chance to reflect enemy shots. Grants one soul heart.
Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
Spawns a familiar that follows Isaac around and fires homing tears.