Item: Iron Bar
Cube of Meat
Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Shows secret and super secret room locations on the map.
Spawns a blue attack fly that orbits a long distance from Isaac.
Ball of Bandages
Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
Spawns a beggar familiar which floats around the room and picks up any nearby coins, leveling up after collecting several coins. At level 2, Bumbo gains a body. At level 3, it begins to fire tears. At level 4, Bumbo chases enemies slowly, dealing contact damage.
A familiar that mirrors the player's movements and shoots in the opposite direction.
Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Causes shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode.
A familiar who will drop a half red heart every 2 rooms.
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
+2.25 Range Up. +1.5 Tear Height. Isaac's tears travel through walls and appear out of the opposite wall. Isaac's tears also travel over rocks and objects.
A familiar that follows behind Isaac. It drips a trail of creep, which slows enemies, and spawns 1-2 blue spiders after each room.
Spear of Destiny
In addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy.
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Grants one red heart container, restores 5 red hearts, and increases speed by 0.3.