Item: Isaac's Heart
Reduces the charge of any Activated Items by 1. Any 1 charge items instead have timed recharges.
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.
Spawns a familiar that will follow Isaac's movements on a 2.5 second delay. Tears that pass through the baby will be doubled and increase in speed.
Tears simultaneously fire out of both eyes diagonally, similar to the effect of the R U A Wizard?pill. Isaac's tears also travel above all obstacles.
The Ludovico Technique
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
Grants a heart container for every 25 coins Isaac has.
Adds a chance to reflect enemy shots. Grants one soul heart.
Increases damage, but also increases the chance of champion enemies appearing.
Crown of Light
Gives Isaac a crown that glows blue when active, and turns gray when inactive. While Isaac has no empty red heart containers, Isaac's tears are replaced with blue diamond tears that deal double damage. Regardless of health, the crown will deactivate for the current room when Isaac takes damage.
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.
Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.
A bag that follows Isaac and drops a random rune every 3 rooms.
Ball of Bandages
Orbiting familiar that deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Cube of Meat.