Item: Jaw Bone
Reveals all special rooms (except secret rooms of any kind).
Spawns a familiar that slowly charges forward and damages enemies in its path.
Increases speed by +0.2 and grants piercing tears.
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Chaos causes items to be chosen from random item pools. When picked up, drops between 1-6 random pickups on the floor.
+5 bombs. Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide). This also affects troll bombs.
Curse of the Tower
Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Replaces tears with a piercing laser with unlimited range.
Spawns 1 of each (non-collectible) item: 1 coin, 1 key, 1 bomb, 1 heart, 1 card, 1 pill, 1 trinket.
Grants quadruple shot but decreases tears.
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
Randomizes all passive items upon pickup and at the start of each succeeding floor.
Lord of the Pit
Grants flight and increases speed.
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Spawns a flying familiar that bounces around the room with a black aura, dealing rapid damage to any enemies inside it. While standing in the aura, Isaac gains a 1.5x tear damage multiplier.