Item: Lemon Mishap
Hurts Isaac without depleting health, activating any items that trigger upon taking damage.
Damages all enemies in the room and slows them and their projectiles down.
The Pinking Shears
Separates Isaac's head and body for the current room. Isaac's head, which now has flight, will be under the player's control, while his body will seek out enemies to attack by contact damage.
My Little Unicorn
Upon use, grants invulnerability and increased speed for five seconds, removing the ability to shoot tears and replacing it with the ability to deal contact damage to enemies.
Shoots 8 tears around Isaac, which retain the damage, shot speed, and special effects of his tears. Each tear shot by Isaac increases item charge by one.
Isaac farts and pushes back nearby enemies.
Upon use, spawns a random item from the current room's item pool, with a chance to spawn A Lump of Coal or The Poop instead.
Consumes Isaac's currently held trinket and applies its effect permanently.
Bombs you place explode only when you use this item. Gives 5 bombs.
Spawns six troll bombs around the room.
Creates a small yellow pool of creep, which damages enemies that cross it.
Damages all enemies in the room, but deals a heart of damage to Isaac with each use.
Damages all enemies and destroys all obstacles. The effect occurs every time a new room is entered for the rest of the floor. Opens doors to the floor's secret and super secret rooms.
Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.
Damages all enemies in the room significantly.
Consumes all pedestal items in the room. Active items will have their effects added to Void, and passive items will grant stat upgrades.
Upon use, grants invulnerability and increased speed for five seconds, but removes the ability to shoot tears.
Opens all doors in the current room when activated, including doors which require a key to open and entrances to secret rooms. Opens the big doors in the first room of both The Chest and the Dark Room.