Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
When hit, summons a white attack fly similar to Distant Admiration for the current room.
Follows Isaac around shooting normal tears.
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Glyph of Balance
Grants 2 soul hearts and modifies drops from Champion Monsters based on certain conditions.
Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
Fires lasers at any enemy in its line of sight and moves based on the direction Isaac is firing tears.
A familiar that follows Isaac around shooting blood tears.
Sack of Sacks
Spawns a sack familiar that has a chance to drop a sack upon clearing a room.
Spawns a white poop familiar, which turns into a white poop when Isaac is hurt.
+1 Luck. Increases chance of winning Shell Game Beggar. (Independent of luck stat)
Range up and makes shot tears revolve around Isaac until they drop.
Decreases damage and replaces right eye tears with a unlimited range, piercing laser which fires continuously.
Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item). Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick). Enemies that were poisoned have a chance to drop a black heart when killed.