Item: Lil Chest
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
Every tear has a small shield which will allow it to block one enemy projectile.
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Allows Isaac to fire tears from the back of his head.
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
Spawns a portable key master that follows Isaac and collects keys, giving random chests in return.
Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.
Tears fired from left eye do increased damage.
A familiar that damages enemies by chasing them as well as inducing the fear effect.
Gives Isaac 5 bombs, and makes all dropped bombs larger, which have an increased blast radius and increased damage.
A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with and has a chance to re-roll pickups that it passes over.
Wanders about the room, occasionally spawning blue spiders.
Sack of Sacks
Spawns a sack familiar that has a chance to drop a sack upon clearing a room.
Grants two soul hearts. Isaac now repels enemy projectiles.
Adds a chance to fire a creep shot that deals double damage and leaves a trail of slowing white creep.
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.