Item: Lusty Blood
Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.
Greatly increases the chance to find sacks.
Increases speed by 0.3 and shot speed by 20%.
+5 range. After Isaac is damaged, a trail of red creep will be left behind Isaac until he leaves the current room.
After every 15 tears fired, Isaac will fire a high-damage cluster of tears.
Shows secret and super secret room locations on the map.
Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Follows Isaac around shooting normal tears.
After taking damage a certain amount of times, a permanent demonic familiar spawns.
A blue head familiar that will follow Isaac and fire tears copying his tear effects and damage.
Spawns an orbital familiar that blocks enemy projectiles, deals contact damage to enemies, and increases the speed of all orbital familiars.
Tears are replaced with piercing white blasts of light.
Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Lord of the Pit
Grants flight and increases speed.
There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.
Head of the Keeper
Isaac's tears become coins and now have a chance to drop pennies on the floor upon successfully hitting an enemy.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Grants 2 Heart Containers and completely restores health.