Item: Magic Mushroom
Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Grants an active item charge every 15 enemies killed.
Grants a reward if all enemies in a room are killed in the order they are marked.
Spawns a familiar that follows Isaac around and has a chance to drop a heart, coin, bomb, or keyafter clearing a room.
Grants Isaac piercing tears that travel through enemies (but not obstacles) instead of breaking on impact with them.
Isaac himself is now immune to all damage, and a heart familiar appears and follows Isaac. If the heart is hurt, Isaac is hurt.
Inflicts poison to enemies who make contact with Isaac. Speed down.
Replaces Isaac's tears with eyeballs that can bounce off of each other. The eyeballs are not limited by range, and will instead dissipate when they stop moving or when hitting an enemy or obstacle.
-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac. Shrunk enemies can be crushed and killed by walking over them.
Randomizes all passive items upon pickup and at the start of each succeeding floor.
Increases damage by 1 and range by 5 for tears fired from the left eye.
Tears have a chance to charm enemies.
Increases chance of finding gold chests and normal chests, but reduces chance of finding pickups.
Spirit of the Night
Grants spectral tears and flight.