An Angel Room door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Daddy Long Legs' shadow follows Isaac and stomps on enemies.
Continuously firing tears for several seconds causes Isaac to drop a Butt Bomb. Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
The Inner Eye
Grants triple shot but decreases tears.
Increases speed by 0.3 and shot speed by 20%.
Spawns a shadow familiar that follows Isaac's movements on a 1 second delay and deals contact damage to enemies.
A familiar that follows Isaac and blocks tears. If a tear hits Farting Baby, there is a high chance for it to fart, which will either knock back, poison, or charm all nearby enemies.
+0.7 tears up. Grants a random item at the start of the next run.
An orbital angel which does 7 contact damage per tick and blocks enemy shots. Upon blocking 10 shots in a room it drops an eternal heart.
+5 Bombs. Upon exploding, bombs shoot 8 tears off in every direction, similar to Tammy's Head. The tears are affected by any tear modifiers Isaac has on his own tears.
Has a chance to fire tears that inflict bleeding on enemies, causing them to slowly take damage over time.
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player. This allows for a full 360 degree tear firing radius. Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.
Spawns a familiar that follows Isaac around and fires two tears at once in a V-pattern.
Grants a familiar that transforms into another random familiar every 10 seconds.