Grants four soul hearts and fully restores Isaac's red health.
8 Inch Nails
+1.5 Damage Up. Replaces Isaac's tears with nails, which have increased knockback.
Increases Damage and Speed, plus adds one Soul Heart.
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.
Grants a prism orbital with a large orbital radius. Tears that pass through the prism split into four multi-colored tears.
While Isaac has no red hearts, this item grants flight and a random chance to activate an invincibility shield for a few seconds. If Isaac gains any red hearts, these benefits will disappear.
Key Piece 1
Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Increases damage by a flat 0.1 and grants a soul heart. Enemies can randomly become briefly charmed or feared. Taking damage has a chance to spawn a rainbow poop.
Missing Page 2
Gives 1 black heart. Upon taking damage that reduces Isaac's health to one heart or less, activates The Necronomicon effect, dealing 40 damage to all enemies in the room.
Grants a heart container for every 25 coins Isaac has.
Increases damage by 1 and speed by 0.4.
Spawns a bone familiar that circles around Isaac and reflects enemy shots.
Every tear has a small shield which will allow it to block one enemy projectile.