Item: Moldy Bread
Allows Isaac to carry two cards, pills, or any combination of both at the same time. Drops a random card or pill.
The Inner Eye
Grants triple shot but decreases tears.
Contract From Below
Doubles the number of pickups and chests spawned after clearing a room or performing some other triggering action (such as using a blood donation machine), but reduces the chance for any pickups to spawn at all.
Follows Isaac and automatically fires at enemies in its reach.
Doubles damage, halves tears stat, and greatly reduces shot speed.
Dark Prince's Crown
Increases range, tears, and shot speed when at exactly one red heart.
Adds 3 soul hearts. Grants The Wafer effect for the current room upon taking damage.
Increases range and shot height.
Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
Spawns an orbiting razor that damages enemies it touches and inflicts bleeding on enemies, causing them to slowly take damage over time.
Key Piece 1
Combined with Key Piece 2, unlocks the golden gate in the starting room of The Chest and Dark Room to fight Mega Satan.
Spawns an egg familiar, which cracks and turns into a random charmed enemy when Isaac is hurt. The egg regenerates upon entering a different room.
Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
Grants four soul hearts and fully restores Isaac's red health.
Tears up, adds 1 soul heart, and decreases Isaac's size.
Dagger orbits Isaac, dealing very high damage.
Drops a random trinket. Grants a second trinket slot.