Item: Mom's Heels
Adds a chance to fire a piercing tear that instantly kills any enemy that it touches.
Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
Curse of the Tower
Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Shows secret and super secret room locations on the map.
Zodiac will give Isaac a random zodiac item effect that changes after every floor.
Gives Isaac 5 Bombs, and causes all dropped bombs to home towards the closest enemy.
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
Has a chance to drop a random pickup when Isaac takes damage.
Speed down; gains speed while in a room with enemies until gaining My Little Unicorn effect for a few seconds.
Grants 5 bombs. Isaac's bombs leave behind fire that damages enemies upon contact.
Upon picking up a certain amount of health, spawn a permanent angelic familiar.
Spider enemies no longer target or deal contact damage to Isaac.
Gives one extra pickup (1+1 Free version) of Red Hearts, pennies, bombs, and keys. Does not work with blue, black, and half red hearts, nickels, and dimes.
Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.
Spawns a cloud familiar that leaves a trail of tears that damages enemies. Has a chance to spawn damaging beams of light onto enemies that touch the cloud.
Wanders about the room, occasionally spawning blue spiders.
Doubles damage, halves tears stat, and greatly reduces shot speed.