Item: Mom's Key
Increases range and shot speed, while adding 1 Black Heart.
Spawns a bone familiar that can be aimed with the fire buttons and does contact damage.
Guppy's Hair Ball
Loosely follows behind Isaac. Can be swung like a flail by rapidly spinning Isaac in a circle. Grows bigger by killing enemies.
Grants two soul hearts. Isaac now repels enemy projectiles.
Randomizes all passive items upon pickup and at the start of each succeeding floor.
Upon death, the player will respawn as ??? with 3 soul hearts.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Gives Isaac 99 coins. Can be found multiple times in a single playthrough.
Tears fired from left eye do increased damage.
The Ludovico Technique
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
Spawns a fly familiar that orbits around a random enemy and deals 5 damage per tick to enemies it comes in contact with.
A Loki familiar that follows Isaac and shoots 4 tears in a cross pattern.
Grants a chance of converting any red hearts pickups into soul hearts instead.
Isaac's damage increases each time an enemy is hit. Damage is reset upon missing a shot.
Grants one Heart Container and gives 2 Soul Hearts.