Item: Mom's Wig
Increases damage by 0.5, and multiplies it by 1.5x.
Replaces tears with a piercing laser with unlimited range.
After standing still and not shooting for a short time, Isaac turns invincible until he moves or shoots.
Gives Isaac a Gurdy familiar that will charge around the room dealing contact damage to enemies. Lil Gurdy is charged by holding down a fire button and letting go. The longer the button is held, the faster Lil Gurdy will fling itself across the screen. Lil Gurdy can pass over objects and obstacles in the room.
A demonic familiar that follows Isaac and shoots tears identical to Isaac's in terms of damage, range, fire rate, and effects.
The Ludovico Technique
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
Tears start out massive with high damage, and then shrink down and become weaker over a short range.
The Black Bean
When taking damage, Isaac farts, causing poison damage to all enemies in range.
Tears fire sparks of electricity in random directions upon hitting an obstacle or enemy.
Halo of Flies
Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.
Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
Tears are replaced by a laser beam that pierces through all enemies and obstacles in its path and deals high damage. Can only be fired after a short charge-up period.
Causes shops to instantly restock their items when they are bought. Granted by default for every character in Greed Mode.
Grants a full heart container, and a chance to regenerate a half-heart of health every minute of gameplay.
Gives "Turdy Touch" Effect. Enemies that touch Isaac are changed into poop.
Increases damage and grants a charged shot that fires multiple tears in the same fashion as Monstro.
Spawns a Hush familiar that bounces around the room and deals contact damage. While firing tears, it stops moving.
Increases speed by 0.6, range by 5.25, and tear height by 0.5.