Item: Moving Box

Upon use, gives the effect of Treasure Map, The Compass, or Blue Map for the duration of the current floor.

Upon activation, Isaac loses a half-heart (one whole heart in The Womb onwards) for a random amount of coins, similar to the blood donation machine.

When used, teleports Isaac to a random room that has not been explored yet. If all rooms are explored, including secret rooms, it will teleport Isaac to the Devil or Angel room. If all rooms are explored, including the Devil or Angel room, it will teleport Isaac to the I AM ERROR room. If used in a room with enemies, it will teleport Isaac out and back into the exact same room.

Upon activation, Isaac gains a black heart.

Spawns a random charmed boss.

Upon use, spawns certain pickups or itemsdepending on the floor it is used on. Single-use.

Creates a small yellow pool of creep, which damages enemies that cross it.

Spawns a trapdoor that leads to the next floor upon activation. Unlocks The Forgotten when used on a mound of dirt that appears in The Dark Room.

Shoots 10 tears in a circle around Isaac, which retain the damage, shot speed, and special effects (such as poison) of Isaac's tears.

Upon use, petrifies all enemies in the current room for approximately 4 seconds.

Upon activation, 1 coin will be consumed, and a random pickup may drop, similar to the slot machine.

Grants a brief moment of invincibility when the charge bar hits zero. If spacebar is held for an additional second after hitting zero, Isaac will take damage.

When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.

Damages all enemies in the room.

For 1 coin, damages all enemies in the room.

Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.

Kills all enemies in the room, then kills Isaac three seconds later.

Upon use, spawns a random item from the current room's item pool, with a chance to spawn A Lump of Coal or The Poop instead.

When activated, the level ends and is freshly regenerated with new rooms, monsters, and items. Disappears after use.

Spawns two item pedestals.