Item: Mr. Boom
Damages all enemies in the room and slows them and their projectiles down.
Passively grants flight and increased speed. Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack the Sky.
Upon use, for the next two seconds, any enemy shots that come near Isaac are held in place. After the charge is depleted, they are fired back as tears.
When used, converts two soul hearts into a heart container.
Reveals the map (except the Super Secret Room) and drops a random Tarot Card or soul heart.
Book of the Dead
Upon use, spawns a charmed Bony or an orbital bone for each enemy killed in the current room.
Mom's Bottle of Pills
Gives Isaac a random pill, and will cause him to drop any held Q-slot item (If any). The player will only receive six different pill types in one playthrough.
When used, teleports Isaac to a random room that has not been explored yet. If all rooms are explored, including secret rooms, it will teleport Isaac to the Devil or Angel room. If all rooms are explored, including the Devil or Angel room, it will teleport Isaac to the I AM ERROR room. If used in a room with enemies, it will teleport Isaac out and back into the exact same room.
Upon use, inflicts fear to all enemies in the room for 5 seconds.
Has the same effect as the card or rune currently held by Isaac.
Allows Isaac to re-roll collectible items in the current room into other items, depending on the current room's Item Pool.
How to Jump
Gives Isaac the ability to jump (over gaps, spikes, etc.).
Consumes Isaac's currently held trinket and applies its effect permanently.
Book of Revelations
Adds 1 soul heart, increases the chance for a Devilor Angel Room to appear, and increases the chance for the next boss to be a Horseman (except on XL floors and floors with fixed bosses such as Mom).
Upon use, Isaac farts, charming all nearby enemies.
Removes one red heart container in exchange for gaining 3 Soul Hearts.
Sets a big red target on the ground (similar to the Epic Fetus item) which can be controlled with tear controls. After 6 seconds or by pressing space again, a huge explosive missile hits it, which damages all enemies caught in its blast radius.