Item: Mr. Dolly

Grants the player one red heart container, one soul heart, and one black heart.

Upon picking up a certain amount of health, spawn a permanent angelic familiar.

Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.

Pulls pickups towards Isaac.

Spawns a flying familiar for the current room that chases enemies whenever Isaac takes damage.

Gives Isaac a random tear effect every room.
Removed in Afterbirth: The effect given changes upon entering a room.
Added in Afterbirth: The effect changes every 3 seconds.

A purple fly familiar that follows Isaac's movements on a 3 second delay and deals contact damage to enemies.

Spawns two pretty fly familiars that block enemy shots and deal contact damage to enemies.

Whenever Isaac takes damage, a black ring briefly appears around Isaac, dealing damage to all nearby enemies.

Increases range, tears, and shot speed when at exactly one red heart.

Spawns a familiar that follows Isaac and makes other familiars follow it. While firing tears, it stops moving.

Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.

When Isaac is hit, 1 point of an item's charge is filled.

Grants Isaac homing tears.

Isaac is followed by a small bag that drops a Bomb, 1+1 Free, or a Troll Bomb every 3 rooms.

Grants a unlimited range piercing laser with random rate of fire that does not replace tears. The laser might occasionally fire with the effect of a random item or trinket, such as Hook Worm, Spoon Bender or Tiny Planet.

Grants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.

Adds a chance to reflect enemy shots. Grants one soul heart.

+0.3 tears up. Allows Isaac to fire tears diagonally.

Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.