Item: Mr. Mega
Grants -1 Tear Delay and reduces Range. When tears hit an object or deplete their range, they spawn 4 smaller tears, whose Range and Damage scale with Isaac's.
Spawns 3 random trinkets. Taking damage has a small chance to swallow Isaac's currently held trinket, gaining its effect permanently.
Displays Isaac's tear damage and enemy health bars. Spawns a gray spider familiar that wanders around and inflicts a random status effect on any enemies it comes into contact with. Occasionally spawns a blue spider upon clearing a room.
After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
One of two parts necessary to create Mom's Shovel.
Gives Isaac 5 bombs, and makes Isaac's bombs have a chance to drop random pickups or charm enemies when they explode.
-2 Tear Delay. Tears float in position until firing ceases, after which they will fly off in the direction they were shot in.
Increases damage by 1, range by 5.25, and tear height by 0.5.
+5 bombs. Bombs stick to enemies and spawn 2-4 blue spiders if they kill an enemy.
Spawns a familiar that follows Isaac around and collects red hearts. For every one-and-a-half red hearts collected, Dark Bum will generate one soul heart, one hostile Spider or one friendly blue spider.
The Inner Eye
Grants triple shot but decreases tears.
Pull a chain and ball behind you that will damage enemies on contact and is able to break stones.
Bucket of Lard
Grants two empty heart containers and heals Isaac by half a heart, but decreases speed by 0.2.
Follows Isaac and automatically fires at enemies in its reach.
Increases damage as Isaac receives damage. Damage increase stays for the whole floor.
Isaac leaves a trail of black powder on the floor. Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
Eye of Belial
Grants piercing tears. After piercing one enemy, tears start homing and deal double damage.
Upon death, the player will respawn as ??? with 3 soul hearts.