Item: Mysterious Liquid
Whenever a Devil or Angel Room would spawn after defeating a boss, both rooms spawn. Only one can be entered.
Gives an extra life. Upon death, you will respawn in the previous room with full health and lose the 1up!.
A familiar that charges forward and deals touch damage to any enemies in its path.
Spawns a large orbital familiar that blocks enemy projectiles and deals slight contact damage to enemies.
A red attack fly circles further out than the Halo of Flies / Pretty Flies, but closer than Forever Alone. Deals more damage than Forever Alone.
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Fliesdamaging enemies it passes through.
Increases damage by 1, range by 5.25, and tear height by 0.5.
Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
Reveals type of adjacent rooms, including location for secret rooms and super secret rooms.
Sack of Sacks
Spawns a sack familiar that has a chance to drop a sack upon clearing a room.
???'s Only Friend
Summons a big attack fly that can be controlled with the shooting direction-keys.
When Isaac is hit, 1 point of an item's charge is filled.
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Allows Isaac to fire tears from the back of his head.
Tears fired from left eye do increased damage.
Spawns a familiar that charges forward when shooting tears and explodes upon contact with an enemy, damaging and poisoning them. The familiar respawns after a few seconds.
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
Tears leave a small, short lasting pool of creep on impact or when their range is depleted.