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Welcome to The Binding of Isaac item guide. Click on an item to learn more.

Item ID
Icon
Description

X-Ray Vision

76
X-Ray Vision
Reveals and opens all Secret Room and Super Secret Room entrances.
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Virgo

303
Virgo
Grants a chance to trigger the Book of Shadows effect upon taking damage, creating a shield that nullifies all types of damage for 10 seconds. Also converts "bad pills" into "good pills".
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Tough Love

150
Tough Love
Adds a chance to shoot a tooth instead of a tear, which deals greater damage than regular tears.
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Thunder Thighs

314
Thunder Thighs
Destroys rocks upon contact with Isaac. Adds one heart container and lowers Speed.
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There's Options

249
There's Options
There will be 2 items available to choose from after defeating a boss. Choosing 1 item causes the other to disappear.
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The Wafer

108
The Wafer
All sources of damage that would cause more than one half heart of damage are reduced to one half heart instead.
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The Virus

13
The Virus
Inflicts poison to enemies who make contact with Isaac. Speed down.
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The Soul

335
The Soul
Grants two soul hearts. Isaac now repels enemy projectiles.
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The Small Rock

90
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
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The Sad Onion

1
The Sad Onion
Increases Tears by 0.7.
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The Relic

98
The Relic
Isaac is followed by a small blue cross that will drop a Soul Heart every 4 rooms.
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The Polaroid

327
The Polaroid
If the character has half a red heart or no red hearts after taking damage, it triggers the Book Of Shadows effect, creating a shield that nullifies all types of damage for 5 seconds. Also allows entrance into The Chest.
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The Peeper

155
The Peeper
Spawns a familiar that floats slowly around the room on a zig-zag pattern similar to Boom Fliesdamaging enemies it passes through.
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The Parasite

104
The Parasite
Isaac's tears split in two when they hit something.
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The Pact

80
The Pact
Increases damage by 0.5, tears by 0.7 and grants two soul hearts upon pickup.
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The Negative

328
The Negative
If the character has half a red heart or no red hearts after taking damage, it triggers The Necronomicon effect, damaging all enemies in the room. Also allows entrance into the Dark Room.
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The Mulligan

151
The Mulligan
Tears have a 1/6 chance of spawning allied blue flies when they hit an enemy.
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The Mind

333
The Mind
Grants the combined effects of the Blue Map, Treasure Map, and The Compass, revealing the floor layout and all special rooms, including Secret Rooms and Super Secret Rooms.
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The Mark

79
The Mark
Increases Damage and Speed, plus adds one Soul Heart.
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The Ludovico Technique

329
The Ludovico Technique
Instead of firing tears, Isaac controls one floating tear that hover over obstacles. This tear deals constant damage when held in place over an enemy.
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The Ladder

60
The Ladder
Allows Isaac to walk across gaps one square across by automatically placing a ladder between the two walkable sections.
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The Inner Eye

2
The Inner Eye
Grants triple shot but decreases tears.
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The Halo

101
The Halo
Grants one Heart Container, +0.3 Damage, +0.2 Tears, +0.25 Range, +0.3 Speed, and +0.5 Tear Height.
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The Compass

21
The Compass
Reveals all special rooms (except secret rooms of any kind).
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The Common Cold

103
The Common Cold
Adds a chance to shoot poison tears, dealing damage over time when inflicted.
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The Body

334
The Body
Adds 3 heart containers.
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Strange Attractor

315
Strange Attractor
Pickups, trinkets, and monsters are magnetically attracted to Isaac's tears.
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Stigmata

138
Stigmata
Increases damage, and adds 1 heart container.
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Stem Cells

176
Stem Cells
Adds one filled heart container and increases Shot Speed.
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Steam Sale

64
Steam Sale
Reduces all Shop prices by 50%, rounded down to 7 coins for an item, rounded up to 2-3 coins for a pickup.
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Starter Deck

251
Starter Deck
Isaac can hold 2 cards at once and all pills are replaced by cards.
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Squeezy

196
Squeezy
Increases tears by 0.4, and spawns 2 Soul Hearts pickups.
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Spoon Bender

3
Spoon Bender
Grants Isaac homing tears.
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Spirit of the Night

159
Spirit of the Night
Grants spectral tears and flight.
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Spider Bite

89
Spider Bite
Adds a chance to shoot slowing tears, reducing speed of enemy movement and any projectile fired by them.
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Spider Baby

211
Spider Baby
When hit, spawns up to 2 blue spiders.
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Spelunker Hat

91
Spelunker Hat
Reveals type of adjacent rooms, including location for secret rooms and super secret rooms.
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Speed Ball

143
Speed Ball
Increases speed by 0.3 and shot speed by 20%.
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Soy Milk

330
Soy Milk
Tears shrink and do much less damage, but fire in very rapid succession.
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Smart Fly

264
Smart Fly
After Isaac takes damage, this fly will deal continuous touch damage to whatever enemy caused the damage until it is dead. The fly will then systematically attack 1 enemy at a time until the room is cleared.
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Skeleton Key

17
Skeleton Key
Sets your key count to the maximum of 99.
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Skatole

9
Skatole
All types of fly except Boom Fly and Red Boom Fly become passive and slowly move towards Isaac. Does not prevent contact damage.
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Sister Maggy

67
Sister Maggy
A familiar that follows Isaac around shooting blood tears.
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Sissy Longlegs

280
Sissy Longlegs
Wanders about the room, occasionally spawning blue spiders.
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Sharp Plug

205
Sharp Plug
Using an activated item while it's not charged will charge it and Sharp Plug does 2 full heart damage to Isaac.
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Screw

255
Screw
+0.5 tears up, +0.2 shot speed up.
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Rubber Cement

221
Rubber Cement
Tears bounce off walls, enemies, and environmental objects.
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Rotten Baby

268
Rotten Baby
A familiar that spawns blue flies.
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