Item: Odd Mushroom
A Devil Room / Angel Room Door will always spawn after every boss fight, excluding the first floor and floors after Utero II/Womb II.
Increases damage and range while reducing tears and shot speed. Grants homing tears and tears gain a damaging halo.
The Small Rock
Increases damage by 1, increases tears by 0.2, and decreases speed by 0.1.
Increases damage, and adds 1 heart container.
Doubles damage, halves tears stat, and greatly reduces shot speed.
Spawns 2 keys. Generates additional pickups from chests.
Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox. Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Gives Isaac's tears a boomerang effect, and increases range and shot speed.
Spawns a white poop familiar, which turns into a white poop when Isaac is hurt.
Upon taking damage, grants a body part as an orbital, which blocks enemy shots and deals 7 damage per tick to enemies it comes in contact with. The orbitals will be destroyed if they take enough damage from enemies or enemy shots.
Cube of Meat
Orbiting familiar that blocks enemy shots and deals damage to enemies. If collected while already having one, makes the familiar evolve. Only drops from Horsemen. Similar to Ball of Bandages.
Upon death, the player will respawn as ??? with 3 soul hearts.
Adds 5 bombs. Isaac's bombs explode into 2-4 tiny bombs.
Allows Isaac to fire tears from the back of his head.
Isaac's tears decelerate as they travel. Upon stopping or hitting an obstacle, they burst into 8 tears in all directions. Tears can be fired into other tears to feed them, increasing their damage.
Grants two soul hearts. Isaac now repels enemy projectiles.
Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
Spear of Destiny
In addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy.