Item: Pay to Play
A bag that follows Isaac and drops a random rune every 3 rooms.
When Isaac receives damage, the bottle breaks and a puddle of blue creep forms, which damages non-flying enemies, similar to Lemon Mishap. The bottle is reformed upon entering a different room.
Allows Isaac to hold 1 additional trinket.
The Common Cold
Adds a chance to shoot poison tears, dealing damage over time when inflicted.
Spawns an orbiting eye familiar that fires tears every 2 seconds.
Spawns a Mulligan Familiar that will wander the room randomly. Enemies will attack the Mulligan if it's closer.
Grants one Heart Container and gives 2 Soul Hearts.
Upon entering a room with enemies in it, has a chance to spawn a random charmed enemy that persists across rooms.
Isaac's tears gain a random effect that changes every shot.
Shard of Glass
Upon taking damage, Isaac has a chance to drop a full red heart, gain 5 range, and leave a trail of damaging red creep for the current room.
Spawns a Mysterious Paper, increases tears, and grants a bone heart.
Spear of Destiny
In addition to tears, Isaac now holds a spear in front of him which deals damage equal to 2 times his tear damage, and occasionally inflicts fear. The spear cannot be thrown, but deals damage while it is in contact with an enemy.
A cone of light shines in the direction Isaac is moving that slows enemies and enemy shots.
Each time Isaac takes damage, inflicts fear on all enemies in the room and spawns a black Charger familiar that will attack enemies. The Charger will be killed if it is damaged too much.
Sack of Pennies
Isaac is followed by a small bag that drops a coin every 2 rooms.
Suture becomes attached to Isaac, and does touch damage to enemies within its attacking range.